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Featured Publications

T. Ha, Th. Enderle, D.F. Ogletree, D.S. Chemla, P. Selvin, and S. Weiss, “Probing the interaction between two single molecules: Fluorescence resonance energy transfer between a single donor and a single acceptor ,” Proc. Natl. Acad. Sci. U.S.A. 93, 6264 (1996).


S. Myong, I. Rasnik, C. Joo, T.M. Lohman and T. Ha, “Repetitive shuttling of a motor protein on DNA,”Nature 437, 1321-1325 (2005).


C. Joo, S.A. McKinney, M. Nakamura, I. Rasnik, S. Myong and T. Ha, “Real time observation of RecA filament dynamics with single monomer resolution,” Cell 126,  515-528 (2006).

J. Park, S. Myong, A. Niedziela-Majka, K.S. Lee, J. Yu, T. M. Lohman and T. Ha, “PcrA dismantles RecA filaments by reeling in DNA in uniform steps”, Cell 142, 544-555 (2010).


A. Jain, R. Liu, B. Ramani, E. Arauz, Y. Ishitsuka, K. Ragunathan, J. Park, J. Chen, Y. K. Xiang and T. Ha, “Probing cellular protein complexes using single-molecule pull-down”, Nature 473, 484-488  (2011).


R. Zhou, A. G. Kozlov, R. Roy, J. Zhang, S. Korolev, T. M. Lohman and T. Ha, “SSB functions as a sliding platform that migrates on DNA via reptation”, Cell 146, 222-232 (2011).

S. Myong, M. M. Bruno, A. M. Pyle and T. Ha, “Spring-loaded mechanism of DNA unwinding by HCV NS3 helicase,” Science 317, 513-516 (2007).


S. Hohng, R. Zhou, M. K. Nahas, J. Yu, K. Schulten, D. M. J. Lilley and T. Ha, “Fluorescence-force spectroscopy maps two-dimensional reaction landscape of the Holliday junction,” Science 318, 279-283 (2007).


R. Roy, A. Kozlov, T. M. Lohman and T. Ha, “SSB protein diffusion on single stranded DNA stimulates RecA filament formation,” Nature 461(7267), 1092-1097 (2009).